Combination of α-Glycosyl-Isoquercitrin and Soybean Fiber Promotes Quercetin Bioavailability and Glucagon-like Peptide-1 Secretion and Improves Glucose Homeostasis in Rats Fed a High-Fat High-Sucrose Diet

This study examined the effects of a combination soybean fiber and α-glycosyl-isoquercitrin (AGIQ) on improving quercetin bioavailability glucose metabolism in rats fed an obesogenic diet. For 9 weeks, were individually control diet, high-fat high-sucrose (H) H with (HS), or AGIQ (HQ), both (HSQ). Quercetin derivatives plasma, feces, urine, cecal content quantified by high-performance liquid chromatography to assess quercetin, meal tolerance tests performed postprandial glycemia glucagon-like peptide-1 (GLP-1) responses. The HSQ group had higher plasma levels than HQ. was attenuated when compared group. basal GLP-1 concentrations positively correlated derivative concentrations. Hence, could be beneficial for reducing risk intolerance, possibly involving enhanced secretion.